Cendu 40mg Capsule
USV Ltd

prescription required

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In-stock 10 capsules in 1 strip
79.80

NOTICE: unsafe with : Alcohol

USED FOR:
Depression Anxiety disorder Diabetic nerve pain

COMPOSITION:
Duloxetine (40mg)

Therapeutic Uses:
neuro cns

Related Warnings
CAUTION
Alcohol
CAUTION

Cendu 40mg Capsule may cause excessive drowsiness and calmness with alcohol.

WEIGH RISKS VS BENEFITS
Pregnancy
WEIGH RISKS VS BENEFITS

Cendu 40mg Capsule may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

CAUTION
Lactation
CAUTION

Cendu 40mg Capsule is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.

Driving

Cendu 40mg Capsule may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.

Kidney

Cendu 40mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment of Cendu 40mg Capsule may be needed. Please consult your doctor.Dose adjustment is not recommended in patients with mild and moderate kidney disease.

UNSAFE
Liver
UNSAFE

Cendu 40mg Capsule is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Duloxetine   40mg

Uses of Cendu Capsule
Cendu 40mg Capsule is used in the treatment of depression, anxiety disorder, diabetic nerve pain, fibromyalgia, neuropathic pain and stress urinary incontinence.

How to use Cendu Capsule
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cendu 40mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Cendu Capsule works
Cendu 40mg Capsule works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Side Effects:

Common Nausea, Headache, Dryness in mouth, Sleepiness, Dizziness.

Expert advice for Cendu Capsule
You may have to wait for 2 to 4 weeks to get the full effect. If your doctor asks you to stop Cendu, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks. Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate). Inform your doctor if you have ever been diagnosed with kidney or liver problems. It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you. It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine. Monitor blood pressure (BP) frequently.

Frequently Asked Questions

Q. Is Cendu a non-steroidal anti-inflammatory drug (NSAID)?
No. Cendu is not a non-steroidal anti-inflammatory drug (NSAID). It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.

Q. Is Cendu a steroid?
No. Cendu is not a steroid. It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.

Q. Is Cendu a blood thinner?
No. Cendu is not a blood thinner. Blood thinners prevent the formation of harmful blood clots.

Q. Is Cendu a stimulant?
No. Cendu is not a stimulant. Stimulants are the medicines which activate the central nervous system.

Q. Is Cendu a pain killer?
No. Cendu is not a classical painkiller e.g. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).Duloxetine is used for the treatment of chronic pain conditions like neuropathic pain, diabetic neuropathy or fibromyalgia.

Q. Is Cendu a tricyclic antidepressant (TCA)?
No. Cendu is not a tricyclic antidepressant (TCA). It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).

Q. Is Cendu a benzodiazepine?
No. Cendu is not a benzodiazepine. It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Benzodiazepines belong to the sedative-hypnotic class of drugs and include agents like diazepam, lorazepam, alprazolam etc.

Q. Is Cendu a narcotic?
No. Cendu is not a narcotic. It means it does not have habit-forming potential. Narcotics are the substance which can cause addiction and dependence.

Q. Is Cendu a psychotropic?
Yes. A psychotropic is a medicine that affects mind, emotions, and behaviour. Cendu, being an anti-depressant agent reduces the symptoms of depression and is a psychotropic agent.

Q. Can I take Cendu if I have Hepatitis C virus infection?
Cendu should be used with caution in patients with Hepatitis C virus infection. Cases of liver injury, including severe elevations of liver enzymes (>10-times upper limit of normal), hepatitis, and jaundice have been reported with Cendu. Taking Cendu increases the risk of liver toxicity and fatty liver in Hepatitis C virus-infected patients.

Q. What is the peak plasma concentration [Cmax] of Cendu?
The maximum plasma concentration [Cmax] of Cendu is 6 hours post oral dose. Food taken with Cendu may delay the time to reach the peak plasma concentration from 6 to 10 hours. This may marginally decrease the extent of absorption (approximately 11%).

Q. Can I take Cendu with Vitamin D?
Yes. Cenducan be taken with vitamin D. It does not have any known interaction with Vitamin D.

Q. What is half life of Cendu?
The elimination half-life of Cendu ranges from 8 to 17 hours (mean 12 hours).

Q. Which is better in depression, Cendu or fluoxetine?
Fluoxetine has not been found to be different in either tolerability or efficacy when compared with Cendu in major depression. Cendu is good for treating depression, anxiety and may help with chronic pain.

Q. Which is better Cendu vs sertraline?
Cendu and sertraline are found to be equally effective in the treatment of Major Depressive Disorder (MDD). Certain symptoms like agitation and anxiety are reduced better by sertraline. Cendu has been found to be better than sertraline for neuropathic pain.

Q. Which is better for chronic pain, Cendu or pregabalin?
In patients with fibromyalgia Cendu is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Cendu and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).

Q. Which is better Cendu or fluoxetine?
Cendu has been found to be better for the treatment of chronic pain than Fluoxetine. Fluoxetine is good for treating depression and anxiety.

Q. Which is better for depression, Cendu or mirtazapine?
Currently, there is not enough information to firmly recommend one antidepressant over another. However, both these drugs have been found to be safe and efficacious in the treatment of depression.

Q. Which is better for depression, Cendu or venlafaxine?
Currently, there is not enough information to firmly recommend one antidepressant over another. Many doctors favour Cendu over venlafaxine when pain conditions coexist with depression.

Q. Is Cendu a barbiturate?
No. Cendu is not a barbiturate. Barbiturates belong to the Sedative-Hypnotic class of drugs and are likely to have abuse potential.

Q. When to take Cendu?
Cendu can cause difficulty in sleep (insomnia). Hence, it is advised to be taken in the morning than at night.

Q. When does Cendu start working?
Usually, the action of Cendu takes about three to four weeks to appear. Do not discontinue the therapy in between, thinking that it is not effective.

Q. How much dose of Cendu can produce overdose?
Overdose can occur at a doses as low as 1000 mg. Signs and symptoms of overdose (duloxetine alone or in combination with other medicinal products) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia.

Q. How does Cendu work in urinary incontinence?
Cendu is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.

Q. Can I take Cendu with amitriptyline?
It is better to avoid Cendu and amitriptyline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

Q. Can I take Cendu with sertraline?
It is better to avoid Cendu and sertraline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

Q. Can I take Cendu with tramadol?
Cendu and tramadol together can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Please inform your doctor if you are taking any of these medicines before coming to him.

Q. Can I take Cendu with bupropion?
Bupropion can cause inhibition of metabolism of Cendu in the body, resulting in toxic effects of Duloxetine. The concomitant use of these two drugs can result in seizures. Mention it to your doctor if you are taking any of these medications from before.

Q. Which is better in diabetic neuropathy, duloxetine or pregabalin?
In patients with fibromyalgia, Cendu is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Cendu and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).

Q. Can Cendu get me high?
No. Cendu does not cause a high. It does not create a feeling of euphoria and has no recreational potential.

Q. Can I use Cendu for arthritis?
Cendu is not approved for the treatment of arthritis. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Cendu for sciatica?
No, Cendu is not approved for the treatment of sciatica. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Cendu for obsessive-compulsive disorder (OCD)?
Obsessive-compulsive disorder (OCD) is a type anxiety disorder. It is approved for the treatment of obsessive-compulsive disorder. Research studies suggest that Cendu may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder.

Q. Can I use Cendu for hot flashes?
No. Cendu is not approved for use in hot flashes. It may be used in the treatment of depression in postmenopausal women suffering from menopausal vasomotor symptoms (hot flashes, night sweats) and insomnia.

Q. Can I use Cendu for headaches?
No, Duloxetine is not approved for use in headaches. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Cendu for a migraine?
No. Cendu is not approved for use in a migraine. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Cendu for chronic pain?
Cendu is approved for the treatment of chronic pain states including neuropathic pain (nerve pain) associated with Diabetes Mellitus and fibromyalgia.

Q. Can I use Cendu for nerve pain?
Yes. Cendu is approved for use in nerve pain or neuropathic pain conditions, most commonly seen in patients suffering from Diabetes Mellitus.

Q. Can Cendu raise blood sugar levels?
No. Cendu may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.